Physical Examination 
There are no specific findings for metastatic cancer on physical examination. But there may be:
• fever 
• tenderness of the bones 
• tumors under the skin
• enlarged liver and spleen 
• enlarged, hard lymph nodes 
• fluid in the abdomen (ascites) 
• jaundice (the skin turning yellow) 
• swelling of the legs (edema)  

Blood and Other Tests 
• Routine liver function studies—blood tests looking at serum bilirubin and liver enzymes—may be abnormal.
  They can, however, be completely normal even in advanced stages of metastatic cancer.
• There may be serum blood tests that are abnormal. Metastatic colon cancer, for example, may be associated
  with an elevated carcinoembryonic antigen (CEA), testicular cancer with a high alpha-fetoprotein (AFP) and/or
  elevated HCG and ovarian cancer with an elevated CA-125. But not all tumors have specific serum markers.